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TBTU FOR SYNTHESIS
TBTU is an aminium coupling reagent used for amide and ester synthesis. TBTU is a stable, efficient and reactive reagent suitable for solution and solid-phase peptide synthesis. TBTU finds application in the synthesis of biologically active peptides, such as azapeptides.
TBTU is a coupling reagent used for solid-phase peptide synthesis. The compound has been used to study ten different phosphonium and uronium salt-based coupling reagents, which are used to synthesize four peptides.
A new and efficient method for the homologation of urethane protected α-amino acids to its β-homomers by the Arndt-Eistert method using TBTU as a coupling agent is described. Several Fmoc-/Boc-/Z-protected α-amino diazoketone derivatives have been obtained as crystalline solids in good yield. The method is found to be rapid and stereospecific.