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DITHIZONE AR
Dithizone is a sulfur-containing organic compound. It is a good ligand, and forms complexes with many metals such as lead and mercury. Dithizone may be prepared by reacting phenylhydrazine with carbon disulfide, followed by reaction with potassium hydroxide.
Dithizone is used to assess the purity of human pancreatic islet preparations used for transplantation into patients with type 1 diabetes. Dithizone binds zinc ions present in the islet's beta cells, and therefore stains the islets red. Exocrine tissue also present in the preparations does not bind dithizone, and is therefore not stained.Dithizone is a sulfur-containing organic compound. It is a good ligand, and forms complexes with many metals such as lead and mercury. Dithizone may be prepared by reacting phenylhydrazine with carbon disulfide, followed by reaction with potassium hydroxide.
Dithizone is used to assess the purity of human pancreatic islet preparations used for transplantation into patients with type 1 diabetes. Dithizone binds zinc ions present in the islet's beta cells, and therefore stains the islets red. Exocrine tissue also present in the preparations does not bind dithizone, and is therefore not stained.
Indicator for metals.
Dithizone has been used in the preparation of dithizone stain solution for pancreatic islet cells.
Dithizone (Diphenylthiocarbazone) may be used in the following studies:
A lethal dose of cadmium is 2 mg per 1 kg of body weight.
A precipitate is formed immediately upon addition of the carbon disulfide; the mixture becomes warm, and the temperature soon approaches the boiling point. The temperature is maintained just below the boiling point; cooling with ice water may be necessary to keep it there. As the carbon disulfide is added, the mixture soon becomes pasty, then more fluid, and finally pasty again.