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THIOACETAMIDE LR
Thioacetamide has been used as an organic solvent in the leather, tex- tile, and paper industries, as an accelerator in the vulcanization of buna rubber (synthetic polybutadiene), and as a stabilizer of motor fuel.
Thioacetamide (TAA), originally used as a fungicide, is
considered to be one of the most potent hepatotoxicants and carcinogenic agents . It has widely been
used to produce varying grades of liver damage in rats
including nodular cirrhosis, liver cell proliferation,
production of pseudolobules, and parenchymal cell.
necrosis Thioacetamide (TAA), originally used as a fungicide, is
considered to be one of the most potent hepatotoxicants and carcinogenic agents[1]. It has widely been
used to produce varying grades of liver damage in rats
including nodular cirrhosis, liver cell proliferation,
production of pseudolobules, and parenchymal cell
necrosis
Tamarix gallica, a hepatic stimulant and tonic, was examined for its ability to inhibit thioacetamide (TAA)-induced hepatic oxidative stress, toxicity and early tumor promotion response in male Wistar rats. TAA (6.6 mmol/kg body wt. i.p) enhanced lipid peroxidation, hydrogen peroxide content, glutathione S-transferase and xanthine oxidase with reduction in the activities of hepatic antioxidant enzymes viz., glutathione peroxidase, superoxide dismutase and caused depletion in the level of hepatic glutathione content. A marked increase in liver damage markers was also observed.